Genetic variations in the matrix metalloproteinase-1 (MMP-1) promoter and risk of susceptibility and/or severity of chronic periodontitis in the Czech population

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Authors	IZAKOVIČOVÁ HOLLÁ Lydie JURAJDA Michal FASSMANN Antonín DVOŘÁKOVÁ Naděžda ZNOJIL Vladimír VÁCHA Jiří
Year of publication	2004
Type	Article in Periodical
Magazine / Source	J Clin Periodontol
MU Faculty or unit	Faculty of Medicine
Citation
Field	Genetics and molecular biology
Keywords	periodontitis; MMP-1; matrix metalloproteinase; haplotype; gene
Description	Matrix metalloproteinase-1 (MMP-1) is a potent enzyme degrading extracellular matrix, which was implicated in the pathogenesis of chronic periodontitis. Therefore, the aim of our study was to examine the association between three promoter polymorphisms of the MMP-1 gene and chronic periodontitis susceptibility and/or severity in a Czech population.
Related projects:	Molecular pathophysiology of multigene diseases