Frequency dependence of Ito and INa block in ventricular cardiomyocytes: comparison of the effect of ajmaline and propafenone

Bébarová,  Markéta; Matejovič,  Peter; Pásek,  Michal; Šimurdová,  Milena; Šimurda,  Jiří

Frequency dependence of Ito and INa block in ventricular cardiomyocytes: comparison of the effect of ajmaline and propafenone

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2003
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	In contrast to propafenone, ajmaline induces frequency-independent block of INa and Ito. The difference is likely caused by variances in the values of rate constants related to the block of inactivated channels.
Related projects:	Early diagnostics of Cardiovascular Diseases