Analýza frekvenční závislosti působení antiarytmik na srdeční buňky metodou vnuceného akčního napětí
| Title in English | Action potential voltage clamp analysis of frequency dependence of effect induced by antiarrhythmic drugs in cardiomyocytes |
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| Authors | |
| Year of publication | 2003 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The changes in ionic currents related to the rate-dependent changes of the configuration of action potential (AP) waveform were identified by the AP voltage clamp method. In control, the AP duration increases during stimulation (2.5 Hz) after a period of rest (60 s). It is caused by gradual decline of Ito. In the presence of ajmaline (30 mikroM), the decreasing AP amplitude is caused by gradual decline of INa. |
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