The influence of selective agonists at cannabinoid CB1 receptor and CB2 receptor on sensitization to methamphetamine behavioural effects in mice.
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | European Neuropsychpharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural pharmacology; drug dependence and abuse; animal models |
| Description | In the two present experiments we focused on hypothetically different influence of cannabinoid agonists at both CB1 (high density in the CNS) and CB2 (high density outside the CNS) receptor on sensitization to MET in the models of locomotor/exploratory activity and agonistic behaviour in mice. This has also been motivated by our earlier studies in which agonists of CB2 receptor (palmitoylethanolamide and JWH 015) exhibited in higher doses behavioural - antiaggressive effects. CB1 receptor agonist cross-semnsitized to both antiaggressive and locomotion stimulating effect of methaphetamine while agonist of CB2 receptor did not. |
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