Comparison Evaluation of Trough/Peak Ratio Betaxolol Hydrochloride and Metoprolole in Patients with Newly Diagnosed Hypertension.
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Hypertension |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Trough/peak ratio; ambulatory blood pressure monitoring; betablockers |
| Description | One of the important characteristic features of the new antihypertensive drugs is its 24-hour effectiveness. If the drug reaches the mean trough/peak over 50% it can be dosed once daily. Betablockers are one of initial drug choice in young patients with hypertension. We evaluated 60 patients in two groups before and after the 3months of treatment with 20mg betaxolol hydrochloride once daily or 200mg metoprolole once daily. For the peak value we used the mean BP from the 3rd - 6th hour after the using of betaxolol hydrochloride or metoprolole, for the trough value the mean BP from the 22nd to 24th hour of the measurement was used, 30 minutes after getting up in the morning and excluding the influence of the hospital surroundings. Results: Trough/peak ratio betaxolol hydrochloride is 78% by the systolic BP, and it is 77% by the diastolic BP. Trough/peak ratio metoprolole is 75% by the systolic BP, and it is 71% by the diastolic BP. Conclusion: Both drugs, betaxolol hydrochloride and metoprolole have the trough/peak ratio over 70% and it can be dosed once daily. There is no statistically significant difference in trough/peak ratios between betaxolol hydrochloride and metoprolole. |
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