Rat model of depression, behavioural and immune changes after administration of antipsychotic and antiepileptic agents
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Homeostasis |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | animal model; depression; antiepileptics; antipsychotics; rat |
| Description | The olfactory bulbectomy (OB) in rats provides a well established animal model used for screening of drugs with a potential antidepressant activity. While currently some atypical neuroleptics and antiepileptics of the 3rd generation are reported from clinics to show mood stabilizing /antidepressant properties we studied effects of amisulpride (AMS), an atypical antipsychotic agent aproved at present for the treatment of at least dysthymia, and tiagabine (TGB), belonging to the newer antiepileptics, considering their activity in the OB model. Our second objective was to determine in the OB rat model, whether AMS and TGB influence the leukocyte phagocytic activity as a marker of cellular immune function. Only the results of the behavioural part of experiment resemble the reffered effects of classical antidepressants in the OB rats and indicate the hypothesized antidepressant activity of AMS and TGB in the present study. |
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