Impact of phenotyping CYP2D6 in psychiatry

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Authors	ŽOURKOVÁ Alexandra HADAŠOVÁ Eva PILAŘOVÁ Lucie ROBEŠ Miroslav RAVČUKOVÁ Barbora KAŠPÁREK Tomáš
Year of publication	2004
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Medicine
Citation
Field	Psychiatry, sexuology
Keywords	phenotype; genotype; CYP2D6; clinical outcome
Description	The paper deal with comparison of distribution therapeutic efficacy and side effects of long term paroxetine treatment within 50 patients genotyped and phenotyped to determine their metabolic status. No variation in therapeutic efficacy and common adverse effects between subjects classified as poor metabilisers and extensice metabolisers were found. A significantkly higher rate of sexual dysfunction was recored among patients with a PM Phenotype.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems