Heterozygote AG variant of -596 A/G IL-6 gene polymorphism is a marker for cutaneous T-cell lymphoma (CTCL)
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Clinical Immunology |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com |
| Field | Dermatovenerology |
| Keywords | CTCL; IL-6; Gene polymorphism; Marker |
| Description | The aim of the study was to investigate possible associations of IL-6 gene polymorphisms (596 A/G and 174 C/G) with cutaneous T-cell lymphoma (CTCL). In the case-control study, genotype distributions and allelic frequencies in two promoter IL-6 gene polymorphisms in the group of 63 Czech patients with CTCL were compared to those of 105 control non-CTCL subjects matched for aged and sex. The IL-6 gene polymorphisms were determined by PCR with following restriction analysis. A significant difference of 596 A/G IL-6 genotype distribution was found between the CTCL patients and the controls (P=0.002) with almost threefold odds ratio for the heterozygote (AG) genotype in CTCL patients (OR=2.64, P=0.002). No significant differences in genotype distribution and/or allelic frequency of functional -174C/G IL-6 gene polymorphism were observed. The double heterozygote AGCG of both IL-6 promoter polymorphisms was associated with CTCL (OR=2.24, 95% confidence interval 1.17-4.28, P=0.01). Thus, the heterozygote variant of -596A/G promoter IL-6 polymorphism could be considered as a genotype marker for CTCL . |
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