Association of tumour necrosis factor-alpha, lymphotoxin-alpha and HLA-DRB1 gene polymorphisms with Lofgrens syndrome in Czech patients with sarcoidosis

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Authors	MRAZEK František IZAKOVIČOVÁ HOLLÁ Lydie HUTYROVÁ Beata ZNOJIL Vladimír VAŠKŮ Anna KOLEK Vítězslav WELSH KI VÁCHA Jiří DU BOIS R.M. PETŘEK Martin
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Tissue Antigens
MU Faculty or unit	Faculty of Medicine
Citation
Field	Epidemiology, infectious diseases and clinical immunology
Keywords	association; cytokine polymorphism; HLA; LT-alpha; MHC; SNP; TNF
Description	Sarcoidosis is a granulomatous disorder showing a clear association with MHC (HLA) class I and class II genes. In order to investigate whether polymorphisms of nearby pro-inflammatory genes located within the MHC class III region may also contribute to susceptibility to sarcoidosis or to its clinical manifestation, tumour necrosis factor alpha (TNF-alpha) and lymphotoxin-alpha (LT-alpha) genes were chosen for analysis in a case-control study.
Related projects:	Molecular pathophysiology of multigene diseases