Quantitative analysis of ionic concentration changes in tubular system of guinea pig ventricular cardiomyocyte
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Proceedings |
| Conference | Analysis of Biomedical Signals and Images |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | guinea pig; cardiac cell; tubular system; quantitative modelling |
| Description | In this work, we explored the extent of ion concentration changes in the transverse-axial tubular system (TATS) of guinea pig ventricular cardiomyocyte. Computer simulations on a quantitative model revealed a decrease in relative Ca2+ depletion from 15.6 % to 7.1 % when the stimulation frequency increased from 1 Hz to 5 Hz. On the contrary, the relative K+ accumulation increased from 2.4 % to 3.4 %. The relative changes of tubular Na+ were negligible. |
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