Modelling the distribution of [Ca2+] within the cardiac t-tubule:  effects of Ca2+ current distribution and changes in extracellular [Ca2+]

Šimurda,  Jiří; Pásek,  Michal; Christé, Georges; Šimurdová,  Milena

Modelling the distribution of [Ca2+] within the cardiac t-tubule: effects of Ca2+ current distribution and changes in extracellular [Ca2+]

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Authors	ŠIMURDA Jií PÁSEK Michal CHRISTÉ Georges ŠIMURDOVÁ Milena
Year of publication	2004
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	To calculate the spatial and temporal distribution of [Ca2+] within the transverse tubules (t-tubules) of cardiac myocytes, we have developed a model described by partial differential equations. Ca2+ diffusion, and Ca2+ binding at the t-tubule membrane and/or in the t-tubule lumen were modelled for cylindrical (254 nm diameter) t-tubules of finite length.
Related projects:	Early diagnostics of Cardiovascular Diseases