A Computational model of the effects of acidosis on intracellular Ca2+ in rat ventricular myocytes

Langham, Elise; Clayton, Rychard; Pásek,  Michal; Orchard, Clive

A Computational model of the effects of acidosis on intracellular Ca2+ in rat ventricular myocytes

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Authors	LANGHAM Elise CLAYTON Rychard PÁSEK Michal ORCHARD Clive
Year of publication	2004
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	The model of rat ventricular myocyte was used to investigate the physiological consequences of acidosis. The results of simulations were in agreement with experimental observations and showed that acidosis causes increase of intracellular Na+, intracellular Ca2+ and amplitude of Cai transients.
Related projects:	Early diagnostics of Cardiovascular Diseases