Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.

Nagata, Yuji; Prokop,  Zbyněk; Sato, Yukari; Jeřábek,  Petr; Kumar, Ashawi; Ohtsubo, Yoshiyuhi; Tsuda, Masataka; Damborský,  Jiří

Degradation of b-Hexachlorocyclohexane by Haloalkane Dehalogenase LinB from Sphingomonas paucimobilis UT26.

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Authors	NAGATA Yuji PROKOP Zbyněk SATO Yukari JEŘÁBEK Petr KUMAR Ashawi OHTSUBO Yoshiyuhi TSUDA Masataka DAMBORSKÝ Jiří
Year of publication	2005
Type	Article in Periodical
Magazine / Source	Applied and Environmental Microbiology
MU Faculty or unit	Faculty of Informatics
Citation
Web	http://loschmidt.chemi.muni.cz/peg/abstracts/aem05a.html
Field	Genetics and molecular biology
Keywords	b-hexachlorocyclohexane; degradation; haloalkane dehalogenase LinB; HCH; UT26
Description	-Hexachlorocyclohexane (b-HCH) is the most recalcitrant among the a-, b-, g-, and d-isomers of HCH, and causes serious environmental pollution problems. We demonstrate here that the haloalkane dehalogenase LinB, reported earlier to mediate the second step in the degradation of g-HCH in Sphingomonas paucimobilis UT26, metabolizes b-HCH to produce 2,3,4,5,6-pentachlorocyclohexanol.
Related projects:	Biomolecular Center