Comparative study on the influence of methamphetamine and enzyme inducers on the activity of drug-metabolizing enzymes in the rat liver microsomes
| Authors | |
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| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Sborník abstrakt. 55. česko-slovenských farmakologických dnů, 31.8.-2.9. 2005, Hradec Králové |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | methamphetamine; metabolic enzymes; microsomes; rat |
| Description | In the present study there was studied the influence of methamphetamine on the activity of cytochromes P450 and N-acetyltransferase (NAT)in the rat liver microsomes in comparison with the effect of known enzyme inducers: phenobarbital, beta-naphtoflavone and dexamethazone. Methamphetamine significantly inhibited CYP2E1, but, on the other hand, it stimulated NAT. Other investigated enzymes were not significantly influenced. |
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