Behavioural sensitization to methamphetamine stimulatory effects on locomotion: comparative study in mice and rats
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural sensitization; mice; rats; open field; methamphetamine |
| Description | In the Experiment 1, the significant stimulatory MET effects on mouse locomotion were apparent after the first dose (2.5 mg/kg), and the significantly increased effect was measured after the repeated administration. In the Experiment 2, MET at the doses of 2.5 or 5 mg/kg stimulated ambulation of rats in the open field test, however after the repeated administration these effects were decreased (insignificantly after the lower and significantly after the higher dose), however, in both groups stereotypic nose rubbing occurred (stereotypies are defined as one of possible signs of behavioural sensitization, too). In the Experiment 3, the significant stimulatory effect on ambulation of rats measured after the first dose of MET at the dose of 0.5 mg/kg was significantly higher after the 8th dose. |
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