Endocrine and immune changes following chronic treatment with tiagabine and amisulpride in the olfactory bulbectomized rat model of depression

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Authors	PISTOVČÁKOVÁ Jana MAKATSORI Aikaterina DOSTÁLEK Miroslav ŠULCOVÁ Alexandra JEŽOVÁ Daniela
Year of publication	2005
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	olfactory bulbectomy; depression; tiagabine; amisulpride; rat; animal model
Description	The purpose of the study was to test endocrine and immune effects of antiepileptic drug tiagabine (TGB) and atypical neuroleptic amisulpride (AMS) in the well established animal model of depression bilateral olfactory bulbectomy (OB) in rats. The tested drugs elicited changes that resemble those seen following chronic treatment with clinically used antidepressants. Thus, they support further the clinical reports that TGB and AMS in addition to their antiepileptic/antipsychotic efficacy respectively may possess also antidepressant activity.
Related projects:	Plasticity of Regulatory Mechanisms of the Central Nervous Systems