Behavioural effects of selected antiepileptics in mice defeated on social interactions
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Behavioural Pharmacology |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | valproate; carbamazepine; lamotrigine; gabapentin; tiagabine; mice; depression; antiepileptic; social interactions |
| Description | The model of behavioural response of the group-housed non-aggressive male mice repeatedly defeated on paired social interactions with singly-housed aggressive counterparts refers to the spectrum of social conflict-related behavioural profiles. These group-housed mice exhibit a suppressed ambulation in the subsequent open field test compared to the controls without such an aversive social experience. This type of inhibited behaviour might be a model for testing of antidepressant-like drug activities. The present study demonstrates utilisation of the method for analysis of psychotropic antidepressant-like drug effects. Despite that effects of lamotrigine and gabapentin, advocated at present as antidepressants, did not resemble effects of other drugs tested, all clinically used antidepressants (citalopram, valproate, carbamazepine) produced very similar disinhibition of the behaviour suppressed by social defeats. |
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