Autophagy is preferred pathway of camptothecin-induced programmed cell death of v-myb-transformed monoblasts
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Proceedings |
| Conference | Journal of Applied Biomedicine |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | v-Myb; apoptosis; autophagy; camptohecin |
| Description | A damage of programmed cell death pathways is a frequent event during malignant transformation. In this study, we analyzed programmed cell daeth (PCD) in v-myb-transformed BM2 and human U937 promonocytes induced by arsenic trioxide,cycloheximide and camtothecin. The presence of functional v-Myb protein pre-determined the BM2 cells to autophagic pathway of PCD in response to the DNA-damaging agents. The absence of transactivating v-Myb protein allowed activation of PCD pathway marked by mitochondrial membrane depolarization and resulting in necrosis. the fact that the antiapoptotic function of the Myb protein can be overcome by alternative PCD pathway suggests that understanding of molecular mechanisms of autophagy could improve therapy of cancer cells suffering from defective apoptosis. |
| Related projects: |