Mezidruhové srovnání rozvoje behaviorální senzitizace k účinkům metamfetaminu u hlodavců
| Title in English | Interspecies comparison of the development of behavioural sensitization to methamphetamine effects in rodents |
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| Authors | |
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Československá fyziologie |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioural sensitization; methamphetamine; rats; mice |
| Description | Altogether 3 experiments were performed in which a distance run was measured in rodent subjects after acute and repeated administration (8 doses given daily) of vehicle or methamphetamine (MET). In the Experiment 1, the significant stimulatory MET effects on mouse locomotion were apparent after the first dose (2.5 mg/kg), and the significantly increased effect was measured after the repeated administration. In the Experiment 2, MET at the doses of 2.5 or 5 mg/kg stimulated ambulation of rats in the open field test, however after the repeated administration these effects were decreased (insignificantly after the lower and significantly after the higher dose), however, in both groups stereotypic nose rubbing occurred (stereotypies are defined as one of possible signs of behavioural sensitization, too). In the Experiment 3, the significant stimulatory effect on ambulation of rats measured after the first dose of MET at the dose of 0.5 mg/kg was significantly higher after the 8th dose. Thus, the study confirmed in both, mice and rats, the development of sensitization to methamphetamine effects on behaviour in the open field test, but sensitizing reactions of rats were more variable showing in relation to dosage either classical increased locomotion (after the lowest dose) or stereotypic behaviour (after higher doses). |
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