Studium struktury a NMR parametrů N-substituovaných derivátů purinu

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Title in English	Study of structure and NMR parametres of N-substituted purine derivatives
Authors	MALIŇÁKOVÁ Kateřina MAREK Radek TOUŠEK Jaromír HOCEK Michal
Year of publication	2003
Type	Article in Proceedings
Conference	Chemické listy
MU Faculty or unit	Faculty of Science
Citation
Field	Organic chemistry
Keywords	N-substituted purine derivatives; NMR spectroscopy; quantum mechanical calculations
Description	Purine derivatives are extensively studied due to their significant biological activities. Interactions of such compounds with other molecules are determined by electronic distribution, which affects tautomeric equilibria, hydrogen bonding pattern, complexations, and in acidic solutions also the site of protonation. Our study is focused on the differences in electron distribution for various purine derivatives benzylated either in position N3-, N7- or N9- and aims to describe changes in reactivity of the purine system with the place of substitution. Similar changes are expected also in the case of unsubstituted bases. N-substituted purine derivatives are studied by NMR spectroscopy in solution. Experimental results are correlated with data obtained by using quantum mechanical calculations.
Related projects:	Biomolecular Center