Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Proceedings |
| Conference | Haematologica/the hematology journal |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | okadaic acid; retinoic acid; differentiation; apoptosis; monoblast; v-Myb |
| Description | The aim of this study was to explore the functional interaction of retinoic acid (RA)- and okadaic acid (OA)-driven pathways in v-Myb-transformed monoblasts BM2. We found that 10 nm OA induces adherency, cell cycle arrest, phagocytic activity, production of reactive oxygen species, and expression of vimentin in BM2 cells. These features that mark differentiation along monocyte/macrophage pathway are enhanced in BM2 cells upon simultaneous treatment with OA and RA. Interestingly, the 20 nm OA induces rather apoptosis than differentiation of BM2 cells. This pro-apopotic effect of OA was inhibited by RA. These results indicate that pro-differentiation and pro-apoptotic effects of OA on BM2 monoblasts are differently regulated by RA. |
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