New Frequent polymorphism 1765C/T in the Gene Encoding For Transcriptional Represson Oncoprotein Gfi-1 in Cutaneous T-cell Lymphomas (CTCL)
| Authors | |
|---|---|
| Year of publication | 2004 |
| Type | Article in Proceedings |
| Conference | The Journal of Investigative Dermatology |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Gfi-1; gene; polymorphism; cutaneous T-cell lymphoma |
| Description | The allelic variant T of 1765 C/T polymorphism is characterized by extinction of the binding site for AP-1 protein in 3-region of Gfi-1 gene. The homozygote genotype TT seems to be associated with lower OR for CTCL. Therefore, the TT genotype of 1765 C/T polymorphism of Gfi-1 gene may have potentially protective effect against CTCL |
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