Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

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Authors	PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra KELLY John LEONARD Brian
Year of publication	2006
Type	Article in Periodical
Magazine / Source	The International Journal of Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	cannabidiol; mice; depression; olfactory bulbectomy
Description	The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Plasticity of Regulatory Mechanisms of the Central Nervous Systems