Selected endocrine, immune and behavioural changes induced by tiagabine in the olfactory bulbectomy rat model of depression

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Authors	PISTOVČÁKOVÁ Jana DOSTÁLEK Miroslav ŠULCOVÁ Alexandra JEŽOVÁ Daniela
Year of publication	2006
Type	Article in Periodical
Magazine / Source	European Neuropsychopharmacology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Description	The study investigated the influence of tiagabine on stress hormone release, cellular immune function and behaviour in rats following olfactory bulbectomy (OB), a well-recognized animal model of depression. The data acquired support the antidepressant-like action of tiagabine and encourage further research on its use in the treatment of affective disorders.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.