The influence of gender and administration of bupropion on the activity of hepatic CYP 450 2D2 in rats

• Authors: ZENDULKA Ondřej; ZAHRADNÍKOVÁ Lucia; JUŘICA Jan; HADAŠOVÁ Eva
• Year of publication: 2006
• Type: Article in Proceedings
• Conference: Collegium Internationale Neuro-Psychopharmacologicum, Final Program and Book of Abstracts.
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: cytochrom P 450 bupropion
• Description: We observed different activity of selected CYP 450 isoenzymes due to gender and administration of antidepressant bupropion. CYP 2D2 activity in higher in female rats and activities of CYP 2C6 and 1A2 were higher in males than in females.

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