HPLC STANOVENÍ MIDAZOLAMU A JEHO METABOLITŮ V PLAZMĚ A PERFUZNÍM MEDIU

Juřica,  Jan; Tomandl,  Josef; Dostálek,  Miroslav; Zendulková Zahradníková,  Lucia; Zendulka,  Ondřej; McCaskey Hadašová,  Eva

HPLC STANOVENÍ MIDAZOLAMU A JEHO METABOLITŮ V PLAZMĚ A PERFUZNÍM MEDIU

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Title in English	HPLC determination of midazolam and its metabolites in plasma and perfuse medium
Authors	JUŘICA Jan TOMANDL Josef DOSTÁLEK Miroslav ZAHRADNÍKOVÁ Lucia ZENDULKA Ondřej HADAŠOVÁ Eva
Year of publication	2006
Type	Article in Proceedings
Conference	Zborník vedeckých prác XIV. medzinárodné konferencie Chromatografické metódy a zdravie človeka
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	HPLC; determination; CYP3A; midazolam
Description	The presented HPLC isocratic method allows to determine midazolam and its three hydroxylated metabolites in plasma and perfusion medium. This method is suitable for modeling and description of possible pharmacological interactions on isoform CYP3A4/5.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions. Capillary electrophoresis as a tool for the drug-metabolism studies Integrované bioanalytické technologie pro mikroanalýzy a diagnostiku s využitím LIF a hmotnostní spektrometrie