Effects of sigma receptor ligand BD737 in rat isolated hearts
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Scripta medica |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | Isolated heart;sigma receptor;electrogram;arrhythmias;rat |
| Description | The present study was focused on possible effects of highly selective, high affinity sigma receptor ligand BD737 in rat isolated hearts perfused according to Langendorff. Electrogram recorded by touch-less method and left ventricular pressure acquired by balloon method were followed during acute exposure of isolated rat heart to nanomolar concentrations of the drug. Ventricular ectopic beats and periods of bigeminy were present in all experiments. Moreover, heart rate fluctuations were observed. In analogy to the positive inotropic effect previously described in isolated rat cardiomyocytes, BD737 exerted a slight insignificant increase of systolic pressure in our experimental model. In conclusion, the inotropic and chronotropic effects of sigma ligand BD737 in nanomolar concentration were confirmed in isolated rat hearts. |
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