No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Nutritional Neuroscience |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | leptin; leptin receptor; proopiomelanocortin; ghrelin; adiponectin; polymorphism; obesity |
| Description | Background: Previously, it has been reported that mutations in the genes encoding for adipokines may be associated with impaired food intake and may serve as potential obesity biomarkers. Aims: The aim of this study was to investigate the possible associations of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin genes with food preferences in obese and non-obese Czech population and evaluate their potential as the obesity susceptibility genes. Material and methods: Using PCR with following restriction analysis, we studied here 185 volunteers. Basic anthropometrical characteristics associated to obesity were measured and the food intake was monitored using 7 day record method. In the group of obese individual, a subset of 34 morbidly obese patients was set off that were available for plasma leptin and soluble leptin receptor levels measurement. Results: None of the examined polymorphisms was associated to anthropometrical or demographic characteristics of the study subjects. The Gln223Arg polymorphism within the leptin receptor gene was significantly associated with lower plasma leptin levels (the RR genotype being more frequent in patients with lower plasma leptin levels, p = 0.001). No associations of the examined polymorphisms with food preferences was observed. Conclusion: Based on our results, the examined polymorphisms in the adipokine genes do not seem to be the major risk factors for obesity development in the Czech population nor significantly affect the food preferences. |
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