Aspergillus fumigatus lectins

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Authors	HOUSER Josef DAŇKOVÁ Věra WIMMEROVÁ Michaela
Year of publication	2008
Type	Article in Proceedings
Conference	Program, sborník přednášek a posterů
MU Faculty or unit	Faculty of Science
Citation
Field	Biochemistry
Keywords	lectin; aspergillus
Description	Aspergillus fumigatus is responsible for hard infections in immunodeficient patients, so called invasive aspergillosis. Lectins present at A. fumigatus surface are of great importance for successful fixation of conidia on human epithelia. Understanding of their interactions with sugar moieties should help us understand A. fumigatus abilities and may play the key role in treatment. Based on sequenced genome there have been found at least 7 lectin-like proteins encoded so far. The aim of our study is bioinformatic search of A. fumigatus lectins followed by studying of recombinant lectins via molecular-biological and biochemical approaches.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Structure-function studies on lectins and adhesins from microbial patogens