Analýza profilů genové exprese u mnohočetného myelomu a jeho význam v klinické onkologii
| Title in English | Analyse of gene expression profiles of multiple myeloma and its significancy for clinical oncology |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Klinická onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | multiple myeloma; microarrays; chips; gene expression profiling (GEP); individual therapy |
| Description | Clinical and genetic heterogeneity is a characteristic feature of multiple myeloma (MM). Despite intensive efforts to clarify the pathogenesis of MM, mechanisms of MM development remain enigmatic. Novel methodological approaches, such as gene expression profiling (GEP), are valuable tools in order to link clinical endpoints, such as response to treatment and surfoval, with th molecular and genetic heterogenity of the disease. The main challenge of current studies is to define diagnostic and prognostic relevance of GEP technologies in a clinical management |
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