Detekce nebalancovaných chromosomových změn u pacientů s mnohočetným myelomem pomocí techniky komparativní genomové hybridizace (CGH)

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Title in English	Detection of imbalanced chromosomal changes in multiple myeloma patients using comparative genomic hybridization (CGH)
Authors	ZAORALOVÁ Romana VRANOVÁ Vladimíra KUGLÍK Petr
Year of publication	2008
Type	Article in Periodical
Magazine / Source	Klinická onkologie, Supplementum
MU Faculty or unit	Faculty of Medicine
Citation
Field	Genetics and molecular biology
Keywords	Multiple myeloma; cytogenetics; chromosomal aberrations; FISH; comparative genomic hybridization
Description	We show an example of use the classic CGH (comparative genomic hybridization) and HR-CGH (comparative genomic hybridization with higher resolution) in five multiple myeloma patients. The aim of the experiments was to complete the results of FISH analyses of other imbalanced chromosomal abnormalities. The other aim was to compare these methods in detecting chromosomal changes in samples with different infiltration.
Related projects:	Molecular basis of cell and tissue regulations University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies