Polymorfizmus genu pro OPRM1 má vztah ke schizofrenii: nový kandidátní gen
| Title in English | OPRM1 polymorphism is in the relationship with schizophrenia: new candidate gene |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Česká a Slovenská Psychiatrie |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | schizophrenia association study polymorphism OPMR1 DNA |
| Description | An abnormality in neurodevelopment is one of the most accepted etiologic hypotheses in schizophrenia. There is strong evidence that genetic factors may influence abnormal neurodevelopment in this disease. Our study was focused on the relationship between functional A118G polymorphism of OPMR1 gene and schizophrenia on the group of 227 males. In our association study we found until now unpublished statistically significant difference of allelic and genotypic frequencies between control and schizophrenic males. According recent knowledge, we hypothesize that OPMR1 gene polymorphism can influence myelinization of CNS neurons through of regulation of expression of OPMR1 receptors on oligodendrocytes. The myelinization of CNS neurons seems to be one of important factor of pathogenesis of schizophrenia. |
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