DNA mikročipy (microarrays) v diagnostice folikulárního lymfomu: cesta k terapii "šité na míru" nebo slepá ulička?
| Title in English | DNA microchips (microarrays) in follicular lymphoma diagnostics: the pathway to "tailor-made therapy" or to impasse? |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | folicullar lymphoma; diagnosis; prognosis; gene expression profiling; DNA microarrays |
| Description | Follicular lymphoma (FL), an indolent B-lymphoproliferative disorder, is characterized by a long median survival of 8 to 10 years. Transformation to more aggressive lymphoma with poor prognosis occurs in 25-60% of patients with FL. Up to now; FL is considered to be an incurable disease with unpredictable individual course. Translocation t(14;18), the traditional genetic hallmark of FL, is of limited clinical improtance only. Prognostic and laboratory parametrs actually used have not been successful in individual stratification of FL patients as well. DNA microarrays enables analyses of the genomic expression program providing new insights into molecular pathogenesis of tumours. Gene expression profiling can reveal morphologically indistinguishable subgroups with different clinical behaviour in the frame of single disease, new important genes or prognosis based on molecular features. |
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