Polymorfizmus genu pro OPRM1 a schizofrenie: nové výsledky asociační studie

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Title in English	OPRM1 gene polymorphism and schizophrenia: new results of association study
Authors	ČASTULÍK Lukáš LOCHMAN Jan PŘIKRYL Radovan ŠERÝ Omar
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Psychiatrie
MU Faculty or unit	Faculty of Science
Citation
Field	Psychiatry, sexuology
Keywords	schizophrenia association study polymorphism OPRM1 DNA gene
Description	Etiology of schizophrenia is associated with disruptions in neural development. Neurodevelopment theory is supported by quite strong genetic evidence. In our study, we studied the relationship between functional A118G polymorphism of OPRM1 gene and schizophrenia. The results showed statistically significant difference of allelic and genotypic frequencies between control and schizophrenic males. According recent knowledge, we suppose that OPRM1 gene polymorphism can influence myelinization of CNS neurons through regulation of expression of OPRM1 receptors on oligodendrocytes. Process of myelinization of CNS neurons seems to be an important factor of pathogenesis of schizophrenia.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Rizikové faktory u perzistentní formy hyperkinetické poruchy (ADHD). Longitudinální, klinická a molekulárně-genetická studie