Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	LUDWIG Heinz HÁJEK Roman TÓTHOVÁ Elena DRACH Johannes ADAM Zdeněk LABAR Boris EGYED Miklós ŠPIČKA Ivan GISSLINGER Heinz GREIL Richard KUHN Ingrid ZOJER Niklas HINKE Axel
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Blood
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	multiple myeloma; thalidomide; dexamethasone; melphalane; prednisone
Description	We compared thalidomide-dexamethasone with melphalan-prednisolone in 289 elderly patients with multiple myeloma. This is the first trial to compare TD with MP in elderly patients. Results in the TD group showed a significantly higher rate of very good responses (CR and VGPR) and significantly shorter time to response with no difference in time to progression and in progression-free survival.
Related projects:	University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies