Chromatin structure and epigenetics of tumour cells: a review.

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Authors	BÁRTOVÁ Eva KREJČÍ J. HÁJEK Roman HARNIČAROVÁ Andrea KOZUBEK Stanislav
Year of publication	2009
Type	Article in Periodical
Magazine / Source	Cardiovascular & Hematological Disorders - Drug Targets
MU Faculty or unit	Faculty of Science
Citation
Field	Genetics and molecular biology
Keywords	chromatin; epigenetics;
Description	Tumour cells are characterized by karyotype instability, which is accompanied by specific events in the chromatin structure and epigenetic patterns. Epigenetics involves heritable changes in the physical and biochemical state of chromatin, which have no effect on DNA sequences; therefore, changes in the nuclear radial arrangement of chromosomes can also be considered epigenetic events.
Related projects:	Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii University Research Centre - Czech Myeloma Group