RELATIONS BETWEEN THREE POLYMORPHISMS IN HLA RELATED GENES AND HEREDITY IN PSORIASIS PATIENTS
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | 6th EADV Spring Symposium on Psoriasis |
| MU Faculty or unit | |
| Citation | |
| Field | Dermatovenerology |
| Keywords | HLA; psoriasis; polymorphism; heredity; comorbidity |
| Description | The aim of the study is to associate two DNA polymorphic genotypes in HLA region (TAP1 Ile333Val, TNFa (-238 G/A) and NcoI TNFb with heredity aspects of psoriasis. A total of 209 Czech psoriatic patients, 110 men and 107 women, aged 52+-15, was enrolled in the study. Careful information about all family members affected by psoriasis was collected. The genotypes in three polymorphisms in HLA related region were detected by PCR methods with restriction analyses. We observed significantly lower occurrence of Val333 TAP-1 allele in patients with family history of psoriasis in the1st degree relatives (P=0.04), especially in parents (P=0.04). For TNFa (-238 G/A) polymorphisms, a significant decrease of the A allele was found in patients with psoriasis reported in the 2nd and the 3rd degree relatives (P=0.01). Similarly, allele B1 of NcoI TNFb polymorphism was less frequent in psoriatic patients with psoriasis documented in the 2nd and the 3rd degree relatives (P=0.008). In conclusion, the detail family history of psoriasis enables to specify more exactly existing associations among heredity aspects of psoriasis and variability in candidate genes of the disease. |
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