Safe allogeneic hematopoietic stem cell transplantation for renal cell carcinoma: Novel approach using selective depletion of alloreactive donor T cells.

Hanák,  Libor; Michálek,  Jaroslav; Matějková,  Eva; Lauerová,  Ludmila; Janečková,  Veronika; Vitetta, Ellen

Safe allogeneic hematopoietic stem cell transplantation for renal cell carcinoma: Novel approach using selective depletion of alloreactive donor T cells.

Warning

This publication doesn't include Institute of Computer Science. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	HANÁK Libor MICHÁLEK Jaroslav MATĚJKOVÁ Eva LAUEROVÁ Ludmila FOLTÁNKOVÁ Veronika VITETTA Ellen
Year of publication	2008
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	It is possible to selectively deplete donor alloreactive T-cells with anti-CD25 IT minimizing or eliminating the risk of GVH disease. This strategy eliminates alloreactivity and preserves GVT reactivity in patients with renal cell carcinoma. Thus the allogeneic hematopoietic stem cell transplantation using selectively allodepleted donor T cells seems to be a valuable alternative to recent treatment strategies.
Related projects:	Bezpečná biotechnologie alotransplatovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie