CHROMATIN ASSOCITED HMGB1 PROTEIN IS INVOLVED IN REGULATION OF TELOMERE LENGTHS IN PLANTS

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Authors	PROCHÁZKOVÁ SCHRUMPFOVÁ Petra GRASSER Klaus FAJKUS Jiří
Year of publication	2009
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	High Mobility Group (HMG) proteins type B bind local DNA structures, promote DNA bending and interact with factors of the transcription, repair and recombination machineries. Arabidopsis thaliana genome encodes 7 HMGB proteins which differ in structure, expression pattern and DNA-binding properties. We observe that HMGB1 takes part in telomere maintenance. Plants lacking HMGB1 display telomere shortening and, consistently, overexpression of HMGB1 leads to telomere elongation.
Related projects:	Molecular basis of cell and tissue regulations Understanding of HMGB1 protein involvement in maintaining genome stability Characterisation of functional diversity of the plant-specific SMH family of proteins