Vztah mezi hladinami methylovaných argininů (ADMA a SDMA), genetickou variabilitou v reninangiotenzinovém systému a postižením ledvin u diabetes mellitus 2. typu
| Title in English | Relationships between levels of methylated arginines (ADMA, SDMA), genetic variability of the reninangiontensin system and diabetic kidney disease in type 2 diabetes mellitus |
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| Authors | |
| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | L arginine,ADMA and SDMA can both affect production of NO (regulation of renal hemodynamics). However, rather than inhibition of NO production by ADMA, pathologic activation of RAS and subsequent increase of oxidative stress (ACE ATIIR1 NAD(P)H oxidase pathway) play more significant pathogenic role. The aim of the study was to investigate i) relationship between plasma levels of L arginine, ADMA and SDMA and stage of diabetic kidney disease and ii) relationship between levels of methylated arginines, genetic variability in the RAS and stages of diabetic nephropathy. Significant correlation between the stage of kidney disease and L-arginine (negative) and ADMA, SDMA (positive) was ascertained (P < 0.05, Spearman). ADMA and SDMA significantly correlated with both components of diabetic kidney disease, i.e. proteinuria and GFR (P < 0.01, Spearman). Multiple regression identified ADMA and SDMA however, none of the RAS polymorphisms (ACE, AGT and ATIIR1) analysed, as a significant predictor of renal outcome. |
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