Pa-IIl-Like Lectins In Human Pathogen Burkholderia Cenocepacia
| Title in English | Pa-Iil-Like Lectins In Human Pathogen Burkholderia Cenocepacia |
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| Authors | |
| Year of publication | 2009 |
| Type | Article in Proceedings |
| Conference | 15th Europian Carbohydrate Symposium |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | Burkholderia cenocepacia; lectin; structure function characterisation; |
| Description | Pathogen recognition and adhesion to the host cell surface is usually mediated by protein-carbohydrate interactions. Chronic pulmonary colonization by opportunistic pathogens like Pseudomonas aeruginosa or bacteria associated with so-called Burkholderia cepacia complex (BCC) is the main reason of death among cystic fibrosis patients. Searching in databases for proteins displaying sequence similarities to PAIIL revealed new homologous proteins in other opportunistic pathogens like Chromobacterium violaceum, Ralstonia solanacearum and even three to four copies, depending on the strain, in Burkholderia cenocepacia, a member of BCC. The contribution is focused on structure-function characterisation of lectins from B. cenocepacia that we identified in its genome. All of the can bind to fucosylated and/or mannosylated oligosaccharides. Except the shortest one, BclA, other three proteins contain an extended N terminal domain of unknown function showing no sequence similarity with any protein in amino acid databases. |
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