Phenotype of plasma cells in multiple myeloma and monoclonal gammopathy of undetermined significance
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Neoplasma |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.neoplasma.sk/ |
| Field | Oncology and hematology |
| Keywords | flow cytometry; plasma cells; monoclonal gammopathy; multiple myeloma |
| Description | The aim of this study was to find possibilities and limits of multicolour flow cytometry in diagnostics of monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM) and to identify parameters that could be used to differentiate between these two disorders. In bone marrow, the percentage of residual polyclonal CD19+ plasma cells was higher (p<0.001) and the percentage of malignant monoclonal CD56+ plasma cells was lower (p<0.001) in MGUS than in MM. The relative counts of CD19+ plasma cells permitted unequivocal differentiation of MGUS from all clinical stages of MM. Flow cytometry is relatively quick and effective method for analysis of plasma cells thus immunophenotyping can significantly contribute to the differential diagnosis of plasma cell proliferations. |
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