Baroreflex sensitivity and essential hypertension in adolescents.
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Physiological Research |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | Essential hypertension; Baroreflex sensitivity; Adolescents; Obesity; Genetics |
| Description | There are several known factors implicating the association of low baroreflex sensitivity with hypertension, e.g. high blood pressure leads to remodeling of the carotid arterial wall, to its stiffness and to a diminished activation of baroreceptors; leptin released from a fatty tissue activates the sympathetic nervous system. Low baroreflex sensitivity (BRS, in ms/mmHg) can be inborn. Studies on primary hypertension in children and adolescents have brought new information about the role of baroreflex in the development of an early stage of primary hypertension. BRS lower than 3.9 ms/mmHg was found in 5 % of healthy subjects. The contribution of obesity and BRS to the development of hypertension in adolescents was also compared. Both factors reach sensitivity and specificity between 60 % and 65 %, but there is no correlation between the values of the body mass index and BRS. Low BRS is an independent risk factor for the development of primary hypertension. |
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