Electrochemical behavior of DNA and RNA heptamers at a mercury electrode

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Authors	TRNKOVÁ Libuše BALCAROVÁ Zdeňka NEPLECHOVÁ Kamila
Year of publication	2009
Type	Article in Proceedings
Conference	Chemické Listy 103, Modern Electroanalytical Methods 2009
MU Faculty or unit	Faculty of Science
Citation
Field	Electrochemistry
Keywords	heptamer; electrochemistry
Description	Hairpins play an important role in many biological processes, including the triplet repeat expansion associated with neurodegenerative diseases. They also form a part of several anomalous DNA or RNA arrangements as triplexes or quadruplexes. The shortest and most stable hairpin yet characterized is formed by the DNA heptamer d(GCGAAGC). This sequence is found in replication origins of herpes simplex virus, in a promoter region of an Escherichia coli heat-shock gene, and in rRNA genes. We studied the shortest hairpin d(GCGAAGC) and r(GCGAAGC) and several other hairpins whose loop sequence is different.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine