Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation

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Authors	GREŠLIKOVÁ Henrieta ZAORALOVÁ Romana FILKOVÁ Hana NĚMEC Pavel OLTOVÁ Alexandra KUPSKÁ Renata RUDOLECKÁ Petra SMETANA Jan POUR Luděk ZAHRADOVÁ Lenka KREJČÍ Marta BÜCHLER Tomáš ADAM Zdeněk HÁJEK Roman KUGLÍK Petr
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Neoplasma
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	multiple myeloma; cytogenetics;FISH;chromosomal abnormalities;transplantation;chemotherapy.
Description	Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are considered important prognostic indicators in MM patients. We have studied samples from 68 patients with newly diagnosed MM who were treated with high-dose chemotherapy and autologous stem cell transplantation. Our results show a high incidence of chromosomal abnormalities in MM patients and confirm the prognostic impact of selected chromosomal aberrations as well as cumulative effect of multiple cytogenetic changes occurring simultaneously.
Related projects:	Molecular basis of cell and tissue regulations University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies