Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma

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Authors	DEMENTYEVA Elena Vladimirovna NĚMEC Pavel KRYUKOV Fedor MUTHU RAJA Karthick Raja SMETANA Jan ZAORALOVÁ Romana GREŠLIKOVÁ Henrieta KUPSKÁ Renata KUGLÍK Petr HÁJEK Roman
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Leukemia Research
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	Multiple myeloma; B-cells; Plasma cells; Centrosome amplification
Description	Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy.
Related projects:	Molecular basis of cell and tissue regulations University Research Centre - Czech Myeloma Group From classic prognostic markers to clinical applications in selected pharmacogenomic and pharmacoproteomic projects in multiple myeloma and monoclonal gammapathies Vytvoření prognostického panelu u pacientů s monoklonální gamapatií nejasného významu s cílem zabránění transformace v maligní onemocnění