Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

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Authors	BLÁHA Luděk BABICA Pavel HILSCHEROVÁ Klára UPHAM B.
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Toxicon
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1016/j.toxicon.2009.07.009
Field	Environment influence on health
Keywords	GJIC; MAPK; cyanobacteria
Description	Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Tumor promotional mechanisms of cyanobacterial metabolites