Numerical defects in CD8+CD28- T-suppressor lymphocyte population in patients with type 1 diabetes mellitus and multiple sclerosis

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Authors	MIKULKOVÁ Zuzana PRAKSOVÁ Petra ŠTOURAČ Pavel BEDNAŘÍK Josef ŠTRAJTOVÁ Lucie PACASOVÁ Rita BĚLOBRÁDKOVÁ Jana DÍTĚ Petr MICHÁLEK Jaroslav
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Cellular Immunology
MU Faculty or unit	Faculty of Medicine
Citation
Field	Immunology
Keywords	Type 1 diabetes mellitus; Multiple sclerosis; Autoimmune diseases; Regulatory T-cells; Suppressor cells
Description	Type 1 diabetes mellitus and multiple sclerosis are organ-specific autoimmune diseases leading to an attack of auto-aggressive lymphocytes against the pancreatic beta-cells and central nervous system, respectively. Using four-colour flow cytometry, T-lymphocyte populations having an important function in autoimmune processes were analyzed. The observed data demonstrate significant differences among patients with T1D and MS in comparison to healthy individuals.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.