An unusual loss of EGFR gene copy in glioblastoma multiforme in a child: a case report and analysis of a successfully derived HGG-02 cell line

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Authors	VESELSKÁ Renata ŠKODA Jan LOJA Tomáš ZITTERBART Karel PAVELKA Zdeněk ŠMARDOVÁ Jana VALÁŠKOVÁ Iveta HERMANOVÁ Markéta ŠTĚRBA Jaroslav
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Child's Nervous System
MU Faculty or unit	Faculty of Science
Citation
Field	Oncology and hematology
Keywords	glioblastoma multiforme; EGFR ; p53; FISH; FASAY; karyotyping
Description	This study report on a case of glioblastoma multiforme with a polyploid karyotype including a very unusual genetic change - the loss of a copy of the EGFR gene at locus 7p11.2 (EGFR gene) - diagnosed in a 14.5-year-old boy. To date, this patient has survived event-free for 34 months. A detailed analysis of the HGG-02 cell line, which was derived from this primary tumor, was also performed.
Related projects:	Diagnostický a prediktivní význam molekulárně cytogenetických markerů u embryonálních nádorů dětského věku