MicroRNA v patogenezi chronické lymfocytární leukemie a jejich prognostický význam
| Title in English | MicroRNAs in pathogenesis of chronic lymphocytic leukemia (CLL) and their prognostic significance |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Bcl-2; microRNA (miRNA); p53 |
| Description | MicroRNAs (miRNAs) are small RNA molecules acting as post-transcriptional regulators of gene expression. They are dynamically regulated during cell differentiation, proliferation and apoptosis. The predicted number of human miRNAs is approximately 1000 and they regulate about 20-30 % of all expressed proteins. Many studies have shown that miRNAs are aberrantly expressed in cancer cells, suggesting that they might act as a novel class of oncogenes or tumor supressors. First evidence of involvement of miRNAs in cancer came from molecular studies characterizing the 13q14 deletion in human chronic lymphocytic leukemia. Two miR genes are located at 13q14.3 and both of these genes, miR-15a and miR-16-1, are down-regulated in more than 60% of CLL cases. Moreover, miRNAs expression can be associated with known prognostic markers in CLL (expression of ZAP-70, unmutated IgVh vs mutated IgVh, deletion and/or mutation of p53 gene).Several microRNAs deregulated in CLL cells target genes which were previously proposed to be involved in CLL pathogenesis or cell cycle regulation suggesting their possible role in disease progression/pathogenesis. |
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